TRIAZOLCARBOXAMIDE DERIVATIVES Russian patent published in 2017 - IPC C07D401/12 C07D403/12 C07D413/12 C07D413/14 A61K31/4192 A61K31/4196 A61K31/4439 A61K31/5377 A61P25/00 

FIELD: pharmacology.

SUBSTANCE: invention relates to compounds of the formula I. In formula IR¹ is phenyl or pyridinyl optionally substituted by halogen, lower alkyl, lower alkoxy, lower alkyl, substituted halogen, and lower alkoxy substituted by halogen; X¹ is -N = or CH; X² is a CR² or =N-; X³ is -N= or CH; provided that only two of X¹, X² or X³ are nitrogen; where is a triazole group selected from , or ; R² is hydrogen or lower alkyl; Z is a bond, -O- or -CH₂-. The compounds of the invention possess affinity for the receptors associated with trace amines (TAAR). The invention also relates to pharmaceutical compositions and to application of a compound for drug manufacture.

EFFECT: new compounds of formula I are obtained that have a high affinity for the receptors associated with trace amines, especially TAAR1.

12 cl, 1 tbl, 36 ex