AMINOPYRIDINE DERIVATIVES AS MODULATORS OF LEUCINE-RICH REPEATED KINASE 2 (LRRK2) Russian patent published in 2017 - IPC C07D239/47 C07D239/48 C07D403/10 C07D405/10 C07D401/10 A61K31/506 A61K31/5377 A61P25/16 

FIELD: pharmacology.

SUBSTANCE: compounds are designed to treat a disease such as Parkinson's disease, in particular hereditary Parkinson's disease. In formula I,

m is from 0 to 1; -NR^a-; -O-; or -S(O)_r- where r is from 0 to 2 and R^A is hydrogen; R¹ is C_1-6-alkyl; R² is halogen; cyano; or halo-C_1-6-alkyl; R³ and R⁴ are independently halogen; C_1-6-alkyl; C_1-6-alkoxy; halo-C_1-6-alkyl; or halo-C_1-6-alkoxy; or R³ and R⁴ together with the atoms to which they are attached, can form a five- or six-membered ring which optionally includes one or two heteroatoms independently selected from O; and R⁵ is C_1-6-alkylsulfonyl; or cyano.

EFFECT: increased efficiency of treatment.

17 cl, 3 tbl, 32 ex