CASMYLATE SALT Russian patent published in 2017 - IPC C07D401/10 A61K31/4439 A61P25/28 

Abstract RU 2638175 C2

FIELD: chemistry.

SUBSTANCE: invention relates to the field of organic chemistry, namely, to camsylate salt of (1r,1'R,4R)-4-methoxy-5"-methyl-6'-[5-(prop-1-yn-1-yl)pyridin-3-yl]-3'H-dispyro[cyclohexane-1,2'-indene-1'2'-imidazole]-4"-amine. The invention also relates to a pharmaceutical composition comprising this salt and a method of treatment based on the use of said camsylate salt. .

EFFECT: new salt is produced, useful in the treatment of Aβ pathologies, such as Alzheimer's disease, Down's syndrome, β-amyloid angiopathy.

10 cl, 1 dwg, 2 tbl, 7 ex

Similar patents RU2638175C2

Title Year Author Number
SUBSTITUTED N-ARYLBENZAMIDES AND RELATED COMPOUNDS FOR TREATING AMYLOID DISEASES AND SYNUCLEINOPATHY 2005
  • Snou Alan D.
  • Ngujen Bet P.
  • Lehjk Tomas P.
  • Kastillo Dzherardo M.
  • Vajgele Manfred
RU2381213C2
SULPHATE SALTS OF N-(3-(4-(3-(DIISOBUTYLAMINO)PROPYL)PIPERAZIN-1-YL)PROPYL)-1H-BENZO[D]IMIDAZOLE-2-AMINE, PREPARATION THEREOF AND USE OF SAME 2013
  • Byurle Stefan
  • Estrella Sesiliya
  • Bare Mate
  • Melnik Patrisiya
  • Serzhan Nikola
  • Byue Lyuk
  • Vervard Filipp
RU2655454C2
1,4 THIAZEPINES/SULPHONES AS BACE1 AND/OR BACE2 INHIBITORS 2012
  • Khilpert Khans
  • Rodzhers-Evans Mark
  • Rombakh Dide
RU2600931C2
BICYCLIC HETEROARYL DERIVATIVES 2019
  • Ratni, Khasan
  • Karter, Dzhennifer Luiz
RU2815806C2
MORPHOLINE TYPE CINNAMIDE DERIVATIVE 2006
  • Kimura Tejdzi
  • Kavano Koki
  • Doi Ehriko
  • Kitazava Noritaka
  • Takaisi Mamoru
  • Ito Koiti
  • Kaneko Tosikhiko
  • Sasaki Takeo
  • Sato Nobuaki
  • Mijagava Takekhiko
  • Khagivara Khiroaki
RU2381225C1
NEW DISPIRO-INDOLINONES, MDM2/p53 INTERACTION INHIBITORS, METHOD FOR PRODUCTION AND APPLICATION 2015
  • Ivanenkov Yan Andreevich
  • Mazhuga Aleksandr Georgievich
  • Beloglazkina Elena Kimovna
  • Beloglazkina Anastasiya Aleksandrovna
  • Veselov Mark Sergeevich
  • Kukushkin Maksim Evgenevich
RU2629750C2
PRODRUG 1,3-DIAMINO-2-HYDROXYPROPANE DERIVATIVES 2003
  • Fobian Ivett M.
  • Freskos Dzhon N.
  • Jagodzinska Barbara
RU2357962C2
DRUG FOR PREVENTION OR TREATMENT OF TAUPATHY 2018
  • Kobayashi Hiroshi
  • Matsumoto Yoshihiko
RU2739199C1
COMPOUNDS TARGETING TAU PROTEIN AND RELATED USE THEREOF 2017
  • Crew, Andrew, P.
  • Berlin, Michael
  • Flanagan, John, J.
  • Dong, Hanqing
  • Ishchenko, Alexey
RU2805523C2
ACYLAMINOTHIAZOLE DERIVATIVES, THEIR PREPARATION AND APPLICATION AS INHIBITORS OF B-AMILOYD PEPTIDES PRODUCTION 2004
  • Despejru P'Er
  • Freehl' Daniehl'
  • Skhunt'Es Brjuno
  • Van Dorsselar Viv'Jan
RU2360907C2

RU 2 638 175 C2

Authors

Bohlin Martin Hans

Stewart Craig Robert

Dates

2017-12-12Published

2013-06-20Filed