FIELD: pharmaceuticals.
SUBSTANCE: group of inventions relates to compounds of formula (I) having the general formula
or a pharmaceutically acceptable salts thereof, also relates to a process for the preparation of compounds of formula (I), comprising the reaction of compound 5
with amine 6
,
forming the said compounds of formula (I) and, if necessary, converting the resulting compounds into their pharmaceutically acceptable salts, also relates to a pharmaceutical composition for modulating gamma secretase containing compounds of formula (I) and a therapeutically inert carrier.
EFFECT: group of inventions provides for the development of compounds as gamma-secretase modulators and their use as part of a medicinal product for the therapeutic and/or preventive treatment of Alzheimer's disease, cerebral amyloid angiopathy, hereditary intracerebral hemorrhage with Dutch type amyloidosis, multi-infarct dementia, boxer dementia or Down syndrome.
13 cl, 4 tbl, 41 ex
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