DRUG FOR PREVENTION OR TREATMENT OF TAUPATHY Russian patent published in 2020 - IPC A61K31/397 A61P25/28 

Abstract RU 2739199 C1

FIELD: medicine.

SUBSTANCE: group of inventions is intended for prevention or treatment of taupathy. Method employs 1-(3-(2-(1-benzothiophene-5-yl)ethoxy)propyl)-azetidine-3-ol or a salt thereof for preventing or treating taupathy. Said agent has action to increase amount of amyloid β protein in cerebrospinal fluid, to reduce amount of amyloid β protein in the brain or by reducing the amount of phosphorylated tau protein in the cerebrospinal fluid or in the brain. Taupathy is Alzheimer's disease, probable Alzheimer's disease, possible Alzheimer's disease, a preclinical stage of Alzheimer's disease, a prodromal stage of Alzheimer's disease, moderate cognitive impairment due to Alzheimer's disease or moderate cognitive impairment. Said agent is used in a patient, which demonstrates progress in increasing the amount of tau protein in the brain or passes the test in order to see the progress in increasing the amount of p-Tau in the brain.

EFFECT: using the group of inventions enables higher effectiveness of treating taupathy.

18 cl, 3 tbl, 3 ex, 5 dwg

Similar patents RU2739199C1

Title Year Author Number
DRUG FOR PREVENTION OR TREATMENT OF BRAIN ATROPHY 2018
  • Kobayashi Hiroshi
  • Matsumoto Yoshihiko
RU2759727C2
METHOD OF DIAGNOSTICS OF NEURODEGENERATIVE DISEASES 2011
  • Jugon Zhak
  • Pake Klehr
  • Djumjurzh'E Zhjul'En
  • Muton-Lizhe Fransua
RU2567665C2
COMPOSITION CONTAINING ANTIBODY AGAINST ABETA PROTOFIBRILS AND INHIBITOR OF BETA-SECRETASE BACE1 FOR TREATMENT OF ALZHEIMER'S DISEASE 2017
  • Satlin, Andrew
  • Fukushima, Tatsuto
RU2786476C2
USE OF LOW-VOLUME PLASMAPHERESIS FOR THE TREATMENT OF EARLY AND MIDDLE STAGES OF ALZHEIMER'S DISEASE 2019
  • Grifols Roura Victor
  • Paez Regadera Antonio Manuel
  • Nu&Ntilde
RU2802628C2
FOOD COMPOSITION FOR PATIENTS SUFFERING FROM PRODROMAL DEMENTIA 2008
  • Khageman Robert Jokhan Jozef
  • Kampkhejs Patrik Jozef Gerardus Khendrikus
  • Brursen Ladislaus Marija
RU2487557C2
THERAPEUTIC VACCINE 2006
  • Pfajfer Andrea
  • Nikolo Klod
RU2440824C2
CASMYLATE SALT 2013
  • Bohlin Martin Hans
  • Stewart Craig Robert
RU2638175C2
COMPOSITION AND METHOD FOR INHIBITING ACCUMULATION, AGGREGATION AND FORMATION OF TAU PROTEIN COILS 2020
  • Kim, Te Gyun
RU2818590C1
PEPTIDE VACCINE FOR PREVENTION AND IMMUNOTHERAPY OF DEMENTIA OF THE ALZHEIMER'S TYPE 2013
  • Van Chan I
RU2696566C2
RECOGNITION IMPROVEMENT 2012
  • Grunendejk Martin
  • Bongers Anke
RU2638809C2

RU 2 739 199 C1

Authors

Kobayashi Hiroshi

Matsumoto Yoshihiko

Dates

2020-12-21Published

2018-06-01Filed