FIELD: pharmacology.
SUBSTANCE: for the treatment or prevention of WHIM syndrome in a person diagnosed with WHIM syndrome, this person is administered a CXCR4 antagonist in an amount effective to treat or prevent WHIM syndrome. The CXCR4 antagonist is 1,1'-[1,4-phenylene-bis (methylene)]-bis-1,4,8,11-tetraazacyclotetradecane or a pharmaceutically acceptable salt or metal complex thereof. A pharmaceutical composition for the treatment or prevention of WHIM syndrome in humans as well as the treatment or prevention of a disorder or condition independently selected from WHIM syndrome, hypogammaglobulinemia, myelocatex, neutropenia, leukopenia or lymphopenia in a person diagnosed with WHIM syndrome is also provided.
EFFECT: effective treatment of these conditions in the patient.
39 cl, 2 dwg, 1 ex
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