1H-PYRAZOLO[3,4-B]PYRIDINES AND THEIR THERAPEUTIC APPLICATIONS Russian patent published in 2019 - IPC C07D471/04 A61K31/444 A61K31/4545 A61K31/496 A61K31/5377 A61P1/02 A61P1/04 A61P11/00 A61P15/08 A61P17/00 A61P19/02 A61P19/08 A61P19/10 A61P25/16 A61P25/28 A61P27/02 A61P29/00 A61P3/04 A61P3/10 A61P35/00 

FIELD: chemistry.

SUBSTANCE: invention relates to organic chemistry and specifically to a heterocyclic compound of formula (I) and a pharmaceutically acceptable salt thereof, where R¹ is H; R² is -(C₁alkyl)_nN (R⁹)₂; R³ and R⁵ are H; R⁴ is -phenyl (R¹³)_q; each R⁹ is independently selected from a group consisting of H, -C_1-3alkyl, -(C_1-3alkyl)_ncyclopentyl and -(C_1-2alkyl)N(R¹⁶)₂; alternatively, two adjacent R⁹ can together with atoms, to which they are bonded, form heterocyclyl(R¹⁷)_q, where heterocyclyl is selected from piperazine, pyrrolidine and piperidine; each R¹³ is a substituent attached to an aryl ring and is independently selected from a group consisting of halogenide, -morpholinyl, -N(R₉)₂ and -(C₁alkyl)_nNHSO₂R¹⁸; each R¹⁶, R¹⁷ and R¹⁸ are methyl; A is C; each q is integer from 1 to 2; and each n is integer of 0 or 1. Invention also relates to a heterocyclic compound of formula (II), values of radicals are given in patent claim, pharmaceutical composition based on compound of formula (I) or (II), a method of treating said diseases and a method of inhibiting one or more Wnt proteins.

I II.

EFFECT: obtaining novel heterocyclic compounds which are useful in treating Wnt mediated diseases.

40 cl, 6 tbl, 10 ex