VIRIONS AND VIRUS-LIKE PARTICLES OF ALTERNANTHERA MOSAIC VIRUS AS AMPLIFIERS OF IMMUNE RESPONSE Russian patent published in 2017 - IPC A61K39/12 A61P37/04 

FIELD: medicine.

SUBSTANCE: virus-like particles are produced in vitro from the protein of the alternanthera mosaic virus (AMV) coat in the absence of RNA. The virus-like particles are produced under physiological conditions by incubating the AMV coat protein in 0.15 M NaCl at pH 7.0-7.5. The group of inventions also relates to a method for enhancing an immune response to an antigen when immunizing animals or human with a mixture of an antigen and an adjuvant, wherein the virus-like AMV particles obtained by the above mentioned method are used as an adjuvant.

EFFECT: use of this group of inventions allows to obtain stable and highly immunogenic virus-like particles which do not differ in size and morphology from full-fledged viral particles, while the AMV coat protein under in vitro physiological conditions can be repolymerised into long spiral structures in the absence of RNA.

2 cl, 6 ex, 6 dwg