IMMUNOGENIC COMPOSITION, CONTAINING FOREIGN ANTIGENS ON SURFACE OF SPHERICAL CARRIERS, OBTAINED BY THERMAL DENATURATION OF SPIRAL VIRUSES Russian patent published in 2012 - IPC A61K39/385 A61K47/06 A61P37/04 B82B1/00 

Abstract RU 2440140 C1

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention relates to medicine, biology, nanothechnology, and deals with obtaining immunogenic compositions. Claimed immunogenic composition contains 1) platform-carrier, for which used are spherical particles, obtained by thermal structural restructuring of viruses belonging to group of tobacco mosaic virus (tobamoviruses) or other plant viruses with spiral structure and 2) foreign proteins/antigens/epitopes, bound with surface of spherical particles. Foreign antigen/epitope in composition of complex with spherical particles demonstrates high immunogenicity and preserves antigenic specificity.

EFFECT: claimed compositions are biologically safe, stable.

10 ex, 13 dwg

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RU 2 440 140 C1

Authors

Atabekov Iosif Grigor'Evich

Karpova Ol'Ga Vjacheslavovna

Kirpichnikov Mikhail Petrovich

Nikitin Nikolaj Aleksandrovich

Trifonova Ekaterina Alekseevna

Chirkov Sergej Nikolaevich

Sheveleva Anna Aleksandrovna

Dates

2012-01-20Published

2010-12-09Filed