FIELD: biotechnology.
SUBSTANCE: invention relates to the production of liposomes with a peptide of the myelin basic protein (MBP), and can be used in medicine for multiple sclerosis treatment. A composition is prepared containing the MBP peptide with SEQ ID NO: 11 or SEQ ID NO: 12 bound to the first vector, wherein the vector comprises a liposome having a surface exposed to the target portion that contains a mannose residue or a mannose derivative.
EFFECT: invention provides greater therapeutic benefit than copaxone, therapeutically approved for the treatment of relapsing-remitting multiple sclerosis.
18 cl, 14 dwg, 14 tbl, 14 ex
| Title | Year | Author | Number |
|---|---|---|---|
| LIPOSOMES CONTAINING OLIGOPEPTIDES - FRAGMENTS OF MYELIN BASIC PROTEIN, PHARMACEUTICAL COMPOSITION AND METHOD OF TREATING MULTIPLE SCLEROSIS | 2009 |
|
RU2448685C2 |
| ANALOGUES OF LONG-ACTING PEPTIDES | 2012 |
|
RU2664859C2 |
| PEPTIDE | 2014 |
|
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| NEUROENDOCRINE FACTORS FOR TREATING DEGENERATIVE DISORDERS | 2008 |
|
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| INJECTABLE DOSAGE FORM OF OLIGOPEPTIDE PREPARATION FOR TREATING MULTIPLE SCLEROSIS AND METHOD FOR PRODUCING IT | 2010 |
|
RU2561582C2 |
| ACTIVIN-ActRIIa-Fc ANTAGONISTS AND USE THEREOF FOR TREATING OR PREVENTING BREAST CANCER | 2008 |
|
RU2473362C2 |
| MODIFIED CELLS WITH CHIMERIC ANTIGEN RECEPTOR FOR TREATING CANCER EXPRESSING CLDN6 | 2020 |
|
RU2826058C2 |
| NOVEL VIRAL VECTOR CONSTRUCT FOR NEURON SPECIFIC CONTINUOUS DOPA SYNTHESIS IN VIVO | 2010 |
|
RU2606012C2 |
| PEPTIDE FROM THE COMPOSITION OF THE IMMUNOGLOBULIN HUMAN HEAVY CHAIN, SUITABLE FOR TREATMENT OF MULTIPLE SCLEROSIS | 2016 |
|
RU2646817C1 |
| RECOMBINANT DEFENSIN EXPRESSION IN FILAMENTOUS FUNGI | 2006 |
|
RU2404990C2 |
