THERAPEUTIC RNA FOR OVARIAN CANCER Russian patent published in 2024 - IPC A61K31/7088 A61K48/00 A61K39/00 C07K14/47 C07K14/705 A61P35/00 

FIELD: medicine; pharmaceutics.

SUBSTANCE: group of inventions relates to therapeutic RNA for treating ovarian cancer. Invention discloses a pharmaceutical composition, a drug preparation and a kit containing at least one RNA which codes: (i) an amino acid sequence comprising claudin 6 (CLDN6), an immunogenic variant thereof or an immunogenic fragment of CLDN6 or an immunogenic variant thereof; (ii) an amino acid sequence comprising p53, an immunogenic version thereof or an immunogenic fragment of p53 or an immunogenic version thereof; and (iii) an amino acid sequence comprising a predominantly expressed melanoma antigen (PRAME), an immunogenic version thereof or an immunogenic fragment of PRAME or an immunogenic version thereof. In another version, each of the amino acid sequences specified in (i), (ii) or (iii) is encoded by a separate RNA.

EFFECT: administration of therapeutic RNAs to a patient suffering ovarian cancer promotes reduction of tumour size, prolongs time to disease progression and/or protects against metastasis and/or tumour recurrence.

83 cl, 29 dwg, 18 tbl, 2 ex