FIELD: biotechnology.
SUBSTANCE: invention relates to a self-immolative chimeric protein for cleaning a target protein, a nucleic acid which encodes it, and also to a vector and a host cell containing the above-mentioned nucleic acid. A method of cleaning a target protein, comprising cultivating the above-mentioned cell, is also disclosed. The invention also relates to a method of producing a therapeutic antibody-drug conjugate using the above-mentioned chimeric protein.
EFFECT: invention allows effictive cleaning of the target protein.
29 cl, 17 dwg, 7 ex
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