METHOD OF PRODUCING 3,8-DIARYL-2,3,4,7,8,9-HEXAHYDROBENZO[1,3]OXAZINO[5,6-h][1,3]BENZOXAZINES Russian patent published in 2017 - IPC C07D265/12 

FIELD: chemistry.

SUBSTANCE: invention relates to the method of producing 3,8-diaryl-2,3,4,7,8,9-hexahydrobenzo[1,3]oxazino[5,6-h][1,3]benzoxazines of the general formula

, Ar = C₆H₅, n-ClC₆H₄, n-BrC₆H₄, n-CH₃C₆H₄, which can be used as drugs with fungicidal, anti-inflammatory, anticonvulsant and anticancer activity. The production method is carried out by reacting N,N-bis (methoxymethyl) -N-aryl (phenyl, n-chlorophenyl, p-methylphenyl, n-bromophenyl) amines with pyrocatechol in the presence of a catalyst of a crystalline nitrate samarium Sm(NO₃)₃ * 6H₂O, taken in the molar ratio N,N-bis (methoxymethyl) -N-arylamine: pyrocatechin: Sm(NO₃)₃ * 6H₂O = 1:1:(0.03-0.07). The reaction is carried out in ethyl ether of acetic acid as a solvent at room temperature (~20°C) and atmospheric pressure for 6-8 hours.

EFFECT: method of selective producing the said compound.

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