FIELD: biotechnology.
SUBSTANCE: characterized strain is isolated from the sick cattle and obtained by successive passages on sensitive hetero- and homologous cell cultures and deposited in the collection of the FGBU "VNIIZZH" under the registration number strain VIA A2269/VNIIZZH/2015 (production), (control cattle), (control swine). The presented strain is reproduced in transplantable cultures of kidney cells of the Siberian mountain ibex (PSGK-30), IB-RS-2, VNK-21. During 17-24 hours of incubation, the virus yield in these cell cultures reaches the values of 6.75-7.75 lg TCD50/cm3. The presented virus strain can be used for control of the antigenic and immunogenic activity and for manufacture of biopreparations for diagnosis and specific prevention of type A foot and mouth disease.
EFFECT: with high multiplicity of infection, causes CPD after 17-24 hours, maintaining the original characteristics when passaging in cell cultures for 5 passages.
5 cl, 1 dwg, 7 tbl, 7 ex
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