FIELD: biotechnology.
SUBSTANCE: invention relates to the field of biotechnology and pertains to a new strain of type A foot-and-mouth disease virus Aphtae epizooticae of the Picornaviridae family, Aphtovirus genus, deposited in the Collection of strains of microorganisms of FGBI ARRIAH under registration No. 339 - dep/20-127 - GCSM FGBI ARRIAH strain A 2205/G - IV type A foot-and-mouth disease virus. The presented strain is reproduced in the continuous cultures of Siberian ibex kidney cells (PSGK-30), in the continuous culture of porcine kidney cells IBRS-2, in the continuous culture of Syrian hamster kidney cells BHK - 21/2-17 for 19 to 20.5 hours of incubation, the virus yield reaches values of 2.13±0.05 mcg/cm3 total viral protein, retaining the initial characteristics when passivating in a cell culture for 5 to 10 passages.
EFFECT: presented strain can be used for manufacturing biological agents for diagnosis and specific prevention of type A foot-and-mouth disease and for monitoring the antigenic activity of vaccines against foot-and-mouth disease.
1 cl, 4 tbl, 2 ex
| Title | Year | Author | Number |
|---|---|---|---|
| A/AFGHANISTAN/2017 STRAIN OF FOOT-AND-MOUTH DISEASE VIRUS APHTAE EPIZOOTICAE OF TYPE A FOR THE MANUFACTURE OF BIOLOGICAL PRODUCTS FOR THE DIAGNOSTICS AND SPECIFIC PREVENTION OF FOOT-AND-MOUTH DISEASE OF TYPE A | 2022 |
|
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| A/IRAN/2018 STRAIN OF FOOT-AND-MOUTH DISEASE VIRUS APHTAE EPIZOOTICAE OF TYPE A FOR THE MANUFACTURE OF BIOLOGICAL PRODUCTS FOR THE DIAGNOSTICS AND SPECIFIC PREVENTION OF FOOT-AND-MOUTH DISEASE OF TYPE A | 2022 |
|
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| A/EGYPT/EURO-SA/2022 STRAIN OF APHTAE EPIZOOTICAE FOOT-AND-MOUTH DISEASE VIRUS FOR MANUFACTURE OF BIOPREPARATIONS FOR DIAGNOSIS AND SPECIFIC PREVENTION OF FOOT-AND-MOUTH DISEASE GENOTYPE A/EURO-SA | 2023 |
|
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| VACCINE FOR EARLY PROTECTION AGAINST FOOT-AND-MOUTH DISEASE FROM STRAIN A 2205/G IV CULTURAL INACTIVATED EMULSION | 2021 |
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| STRAIN O N 2311/ZABAIKALSKY/2016 FOOT AND MOUTH DISEASE VIRUS TYPE APHTAE EPIZOOTICAE TYPE O FOR MANUFACTURING OF BIOLOGICS FOR DIAGNOSIS AND SPECIFIC PREVENTION OF FOOT AND MOUTH DISEASE OF TYPE O | 2017 |
|
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| A/TANZANIA/2013 STRAIN OF APHTAE EPIZOOTICAE FOOT AND MOUTH DISEASE VIRUS OF A/AFRICA/G-I GENOTYPE FOR MANUFACTURE OF BIOLOGICAL PRODUCTS FOR DIAGNOSTICS AND SPECIFIC PREVENTION OF FOOT AND MOUTH DISEASE VIRUS OF A/AFRICA/G-I GENOTYPE | 2023 |
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| A N2269/VNIIZZH/2015 STRAIN OF TYPE A APHTAE EPIZOOTICAE FOOT-AND-MOUTH DISEASE VIRUS FOR CONTROL OF ANTIGENIC AND IMMUNOGENIC ACTIVITY AND FOR MANUFACTURE OF BIOPREPARATIONS FOR DIAGNOSIS AND SPECIFIC PREVENTION OF TYPE A FOOT-AND-MOUTH DISEASE | 2016 |
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| STRAIN OF FOOT AND MOUTH DISEASE VIRUS APHTAE EPIZOOTICAE FOR MANUFACTURING OF BIOLOGICAL PRODUCTS FOR DIAGNOSIS AND SPECIFIC PREVENTION OF FOOT AND MOUTH DISEASE OF SAT-1/X GENOTYPE | 2023 |
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