BICYCLIC COMPOUND Russian patent published in 2018 - IPC C07C229/50 C07D257/04 C07D307/82 C07D311/04 C07D311/58 C07D317/54 C07D333/56 C07C321/28 C07D215/48 C07D335/06 C07D311/74 C07D307/84 C07D319/18 A61K31/195 A61K31/4706 A61K31/351 A61K31/36 A61K31/197 A61K31/343 A61K31/352 A61K31/353 A61K31/357 A61K31/381 A61K31/382 A61K31/41 A61P9/04 A61P9/10 A61P9/12 

FIELD: pharmacology.

SUBSTANCE: in the general formula (1)

(1),

A is an unbranched C₁-C₃ alkylene group, wherein one methylene group is optionally substituted with O or S; n is an integer from 3 to 5; each of X¹ and X² is independently CH or N; each of W¹ and W² is independently a carboxyl group or W¹ is a carboxyl group and W² is a tetrazolyl group; V is a linear or branched C₁-C₈ alkylene group in which one methylene group is optionally substituted by O or S; R is a group selected from the following

,

,

where R¹, R², R³, R⁴ and R⁵ is a hydrogen atom, a halogen atom, a C₁-C₆ alkyl group which may have a substituent group, a C₁-C₆ alkoxy group, a C₃-C₆ cycloalkyl group, a C₃-C₆ cycloalkoxy group, a halogen C₁-C₄ alkyl group, a halogen C₁-C₄ vinyl group which may have a substituent group, an ethynyl group which may have a substituent group, a phenyl group which may have a substituent group on the aromatic ring, a phenoxy group which may have a substituent group on the aromatic ring, a benzyl group, which may have a substituent group on the benzene ring, a phenethyl group which may have a substituent group on the benzene ring, a benzyloxy group which may have a substituent group on the benzene ring, a benzylsulfanyl group which may have a substituent group on the benzene ring, a benzylamino group which may have a substituent group on the benzene ring, a phenyloxymethyl group which may have a substituent group on the benzene ring, a phenylsulfanylmethyl group which may contain a substituent group on the benzene ring, or a phenylaminomethyl group which may have a substituent group on the benzene ring, wherein the substituent group is indicated in the claims, m is an integer of 1 or 2 and each of Y¹ and Y² independently represents methylene, O or S, provided that they both do not represent S.

EFFECT: compounds can be used to prevent or treat disorders associated with soluble guanylate cyclase, such as hypertension, pulmonary hypertension, heart failure, endothelial dysfunction, atherosclerosis, peripheral vascular disease, angina pectoris, thrombosis, myocardial infarction, erectile dysfunction or impaired renal function.

9 cl, 41 tbl, 213 ex