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IPC

C07K5/78(2006-01-01)

A61K38/05(2006-01-01)

A61P31/14(2006-01-01)

(21) (22)

Application

2017110863, 2017-03-31

(24)

Start date

2017-03-31

(22)

Actual filing date

2017-03-31

(45)

Published

2018-01-17

(72)

Inventor

Shibnev Vladimir AleksandrovichDeryabin Petr GrigorevichFinogenova Marina PavlovnaGaraev Timur MansurovichBotikov Andrej GennadevichMishin Dmitrij Vladimirovich

(73)

Holder

Federalnoe Gosudarstvennoe Byudzhetnoe Uchrezhdenie Issledovatelskij Tsentr Epidemiologii I Mikrobiologii Imeni Pochetnogo Akademika N.F. Gamalei" Ministerstva Zdravookhraneniya Rossijskoj Federatsii

CYCLOHEXANOXYCARBONYL-DIPEPTIDE AND ITS ANTIVIRAL ACTIVITY AGAINST HEPATITIS C VIRUS Russian patent published in 2018 - IPC C07K5/78 A61K38/05 A61P31/14

Abstract RU 2641297 C1

FIELD: pharmacology.

SUBSTANCE: invention relates to new synthetic compounds, namely to the N-acyl derivative of dipeptide, which is cyclohexyloxycarbonyl-prolyl-tryptophan (Cho-Pro-Trp-OH). Cho-Pro-Trp-OH inhibits reproduction of the hepatitis C virus (HCV), and also has a virucidal effect against HCV. The compound has a low toxic effect on the monolayer of the transplantable kidney cell line in the pig embryo (SPEV). .

EFFECT: compound can be recommended for creation of new antiviral drugs, used both as an individual agent and as part of compositions for hepatitis C treatment.

3 cl, 6 dwg, 3 tbl, 5 ex

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RU 2 641 297 C1

Authors

Shibnev Vladimir Aleksandrovich

Deryabin Petr Grigorevich

Finogenova Marina Pavlovna

Garaev Timur Mansurovich

Botikov Andrej Gennadevich

Mishin Dmitrij Vladimirovich

Dates

2018-01-17—Published

2017-03-31—Filed