2-QUINALDICARBOXYLIC ACID DERIVATIVES AND THEIR ANTI-INFLUENZA ACTIVITY Russian patent published in 2017 - IPC C07D215/48 C07D401/12 A61K31/47 A61K31/4709 A61P31/16 

Abstract RU 2624906 C2

FIELD: pharmacology.

SUBSTANCE: agent is amino acid derivatives of 2-quinaldicarboxylic acid: 2-quinaldine-seryl methyl ester (Qln-Ser), 2-quinaldine-tryptophanyl methyl ester (Qln-Trp) and 2-quinaldine-alanyl-proline-1(1-adamantyl)ethylamide (Qln-APR), and can be used for development of new antiviral drugs. The invention also relates to a new compound - 2-quinaldine-alanyl-proline-1(1-adamantyl)ethylamide (Qln-APR).

EFFECT: increased antiviral activity of derivatives against influenza A viruses and acting on strains resistant to rimantadine and amantadine.

3 cl, 7 dwg, 4 tbl, 6 ex

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RU 2 624 906 C2

Authors

Shibnev Vladimir Aleksandrovich

Deryabin Petr Grigorevich

Burtseva Elena Ivanovna

Garaev Timur Mansurovich

Finogenova Marina Pavlovna

Kirillova Elena Sergeevna

Botikov Andrej Gennadievich

Dates

2017-07-10Published

2015-12-22Filed