IMPROVED LIPOSOMAL COMPOSITIONS OF LIPOPHILIC COMPOUNDS Russian patent published in 2018 - IPC A61K9/127 A61K31/337 

FIELD: pharmacology.

SUBSTANCE: invention relates to a liposome preparation for cancer treatment comprising a liposome suspension in the aqueous phase, the said liposomes comprise at least one liposomal membrane in which up to 5 mol % of at least one therapeutically active substance having log P of more than 1 and represented by taxane is present, and at least one osmotically active substance is present in the aqueous phase, the osmolarity of the aqueous phase within the liposomes, O_in, is above the osmolarity of the aqueous phase outside the liposomes, O_out, and the difference between O_out and O_in is at least 10 mOsm and up to 2000 mOsm. The invention also relates to versions of a method for preparation of such a liposome drug and to its application for cancer treatment.

EFFECT: increased efficiency of liposomes loading with an active agent and improved stability of formulations.

39 cl, 2 dwg, 18 tbl, 1 ex