N-ACETYL-L-CYSTEINE FOR APPLICATION IN EXTRACORPOREAL FERTILIZATION Russian patent published in 2018 - IPC A61K31/198 A61K31/4045 A61P15/08 

FIELD: pharmacology.

SUBSTANCE: invention is a pharmaceutical composition containing N-acetyl-L-cysteine (NAC) alone or together with (2) selenium in the form of selenomethionine and/or (3) melatonin and/or their physiologically acceptable salts and a suitable carrier or an excipient for application in IVF treatment of infertility in a mammal, characterized by a NAC dose of 50-150 mg/kg of body weight administered intravenously or a NAC dose of 30-45 mg/kg of body weight is administered once daily for 1 to 3 days orally, or alternatively, 600 mg of NAC is administered three times a day orally for three consecutive days in a week, followed by four days without drug administration for a total of three months or more before IVF-treatment.

EFFECT: higher percentage of live births.

1 tbl, 12 cl, 1 dwg