NEW ANTI-INVASIVE COMPOUNDS Russian patent published in 2018 - IPC C07D213/75 C07D239/42 C07D401/12 C07D401/14 C07D403/12 C07D413/12 A61K31/44 A61K31/505 A61P35/00 

FIELD: pharmacology.

SUBSTANCE: invention relates to compounds of the formula

or pharmaceutically acceptable salts thereof, which can be used to prevent, and/or inhibit, and/or treat cancer. In formula (I) A and A' independently represent phenyl or pyridylene group; R₂ represents a hydrogen or alkyl group (C₁-C₄); R₃ represents a 2-pyridyl group, 3-pyridyl group, 4-pyridyl group, 2-pyrimidinyl group, 4-pyrimidinyl group or 5-pyrimidinyl group; R₄ represents a carbonyl group or sulfonyl group; R₅ is a -NH-(CH₂)_(a)-NR₆R₇ group or a 4-methylpiperazinyl group and a is an integer from 1 to 4, R₆ and R₇ independently represent a nalkyl group (C₁-C₄) or R₆ R₇ together with nitrogen atom they are bounded to form a heterocyclic group selected from 4-methylpiperazinyl group, morpholine group, pyrrolidinyl group and piperidine group. The invention also relates to a method for preparation of compounds of formula (I) and a pharmaceutical composition containing them.

EFFECT: improved compounds properties.

16 cl, 6 tbl, 17 ex