FLT3 RECEPTOR ANTAGONISTS Russian patent published in 2020 - IPC C07D233/64 C07D295/26 C07D401/12 C07D235/18 C07D403/04 C07D263/57 C07D249/08 C07D209/08 C07D413/04 C07D413/12 A61K31/506 A61K31/5377 A61K31/4523 A61K31/4453 A61K31/496 A61K31/423 A61K31/4178 A61K31/415 A61K31/4196 A61P35/00 

FIELD: chemistry.

SUBSTANCE: invention relates to a novel compound of formula (2) and variants thereof, which are FLT3 receptor antagonists. In general structural formula (2)

X is CONH or triazolyl; Y is SO₂, Q is selected from a group of formulas:

and ,

where Q₁ and Q₂ are CH; Q₃ is selected from O, S, N and NH; Q₄ is selected from C, N and CO; Q₅ is selected from C and N; R₆ is selected from H, OH, alkyl, hydroxyalkyl and alkoxy, R₁ is OH; R₂ is H; R₃ is selected from H, OR₁₁, halogen and O-(CH₂)_p-O-alkyl; R₄ is selected from H, alkyl, halogen, CN, trifluoromethyl, CO-alkyl, phenyl and benzyl; provided that one of R₃ and R₄ is H; R₅ is H; two of R₂ and R₃, or R₃ and R₄, or R₄ and R₅ together with carbon atoms, to which they are bonded, form an aromatic ring containing 5–6 members, and the rest of R₂-R₅ are H, R₇ and R₈ are alkyl or R₇ and R₈ together with atom N, to which they are attached, form group of formulas:

, or ,

where R₁₀ is selected from H, alkyl, halogen, trifluoromethyl, aryl and hydroxyalkyl, or two adjacent groups R₁₀ together with ring atoms, to which they are bonded, form an aryl group; or R₇ and R₈ together with atom N, to which they are attached form group of formula , where Z is a group NR₁₄, where R₁₄ is selected from phenyl, benzyl and pyrimidyl, or R₇ is H and R₈ is cycloalkyl, preferably cyclohexyl and adamantyl, R₁₁ is H or alkyl; R₁₅ represents a group selected from H, halogen, OH and alkoxy; s is 0, 1, 2 or 3; n is 1 with the exception of N-(5-chloro-2-hydroxyphenyl)-3-(piperidin-1-sulphonyl) benzamide. Invention also relates to versions of the compound of formula (2) - compounds (1), (2a), (2b), (2c) and (2d) and to a group of specific compounds which are described in the patent claim.

EFFECT: inventions can be used for treating pain disorders, pain disorders are selected from neuropathic pain, iatrogenic pain, including cancer pain, infectious pain, including herpetic pain, central pain, nociceptive pain, including postoperative pain, and back pain and orofacial area.

13 cl, 1 tbl, 13 ex