METHOD FOR AMINO ACID COMPOUNDS OBTAINING Russian patent published in 2018 - IPC C07C227/32 C07C229/34 C07C269/06 C07C271/22 C07C67/343 

FIELD: pharmacology.

SUBSTANCE: invention relates to a method for obtaining of a compound of formula or a salt thereof that can find application in the preparation of AKT inhibitors used to treat diseases such as cancer. The method includes asymmetrical reduction of a compound of formula or a salt thereof in the presence of a stereoselective reducing agent to form a compound of formula I. In formulas I and II, R¹ and R² are independently hydrogen, C₁-C₁₂ alkyl or an amino-protecting group. The invention also relates to compounds of formulas and , which are intermediate in the synthesis of the formula I compound. In formula VI, R¹ is hydrogen, acetyl, trifluoroacetyl, phthalimide, benzyl, triphenylmethyl, benzylidenyl, t-butyloxycarbonyl, 9-fluorenylmethyloxycarbonyl or carbobenzyloxy; R² is C₁-C₁₂ alkyl and R⁵ is hydrogen or C₁-C₁₂ alkyl. In formula VIb, R¹ is hydrogen, acetyl, trifluoroacetyl, phthalimide, benzyl, triphenylmethyl, benzylidenyl, p-methoxybenzyl, t-butyloxycarbonyl, 9-fluorenylmethyloxycarbonyl or carbobenzyloxy.

EFFECT: increased application effeciency.

23 cl, 1 dwg, 2 ex