BICYCLIC PYRIDINES AND PYRIMIDINES AS KINASE P38 INHIBITORS Russian patent published in 2007 - IPC C07D471/04 C07D495/04 C07D491/48 C07D487/04 A61K31/4355 A61K31/4365 A61K31/437 A61K31/519 A61P19/02 A61P29/00 A61P25/28 A61P11/06 

FIELD: organic chemistry, biochemistry, medicine, pharmacy.

SUBSTANCE: invention relates to novel compounds of the formula (I): and their pharmaceutically acceptable salts possessing properties of inhibitors of protein kinase p38. In the formula (I) A means nitrogen atom (N) or -CH; R¹ means hydrogen atom, alkyl or aralkyl; R² means (C₁-C₆)-alkyl, hydroxy-(C₁-C₆)-alkyl, (R'')₂NCO-alkylene- (wherein each R'' means independently hydrogen atom or (C₁-C₆)-alkyl), (C₃-C₇)-cycloalkyl substituted optionally with hydroxy-group, 6-membered heterocyclyl comprising nitrogen, oxygen or sulfur atom or its oxides as heteroatoms and wherein nitrogen-containing heterocyclyl can be substituted with (C₁-C₄)-alkylsulfonyl group, optionally substituted phenyl wherein substitutes are chosen from halogen atoms and lower alkoxy-group; X means oxygen atom (O), -NR³ or sulfur atom (S) wherein R³ means (C₁-C₆)-alkyl or phenyl; Y means a chemical bond, O, C(=O), -CH(OR'), -CHR' or S wherein R' means hydrogen atom; R means phenyl optionally substituted with one or some substitutes chosen from halogen atoms, lower alkyl and lower alkoxy-group. Proposed compounds can be used, for example, in treatment of inflammatory diseases, among them intestine disease, Alzheimer's disease, Crohn's disease, cerebrospinal sclerosis, asthma and can be used in development of viral diseases also.

EFFECT: valuable medicinal properties of compounds.

11 cl, 5 sch, 1 tbl