IMIDAZO-CONDENSED COMPOUNDS AND PHARMACEUTICAL COMPOSITION CONTAINING THEREOF Russian patent published in 2007 - IPC C07D471/14 C07D487/14 A61K31/519 A61P25/00 A61P29/00 

FIELD: organic chemistry, medicine, biochemistry, pharmacy.

SUBSTANCE: invention describes novel imidazo-condensed compounds of the general formula (I): wherein Z represents nitrogen atom (N); Z¹ represents N whein a bond between C5 and Z¹ represents a simple bond, and Z¹ represents carbon atom (C) when a bond between C5 and Z¹ represents a double bond; R¹ represents hydrogen atom; R² represents (C₁-C₆)-alkyl, (C₁-C₆)-hydroxyalkyl, phenyl-(C₁-C₄)-alkyl substituted with halogen atom, ((C₁-C₄)-alkyl)-SO₂, (C₁-C₆)-alkyl, (C₅-C₆)-cycloalkyl possibly substituted with hydroxy-group, phenyl substituted with halogen atom, heterocyclyl possibly substituted and chosen from group consisting of tetrahydropyranyl, (N-methylsulfonyl)piperidinyl or tetrahydro-1,1-dioxide-2H-thiopyranyl; A is absent or represents -O-; a bond between C5 and Z¹ is a simple or double bond; a bond between C8 and C9 is a simple or double bond; Y represents phenyl substituted with halogen atom, or their pharmaceutically acceptable salts possessing inhibitory activity with respect to p38 MAP kinase, and pharmaceutical composition containing thereof. Proposed compounds can be used, for example, in treatment/or prophylaxis of such diseases as rheumatic arthritis, fever and reduced bone resorption.

EFFECT: valuable medicinal properties of compounds and pharmaceutical composition.

16 cl, 2 tbl