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2 643 372

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IPC

C07D491/48(2006-01-01)

A61K31/407(2006-01-01)

A61P31/04(2006-01-01)

(21) (22)

Application

2017128191, 2017-08-07

(24)

Start date

2017-08-07

(22)

Actual filing date

2017-08-07

(45)

Published

2018-02-01

(72)

Inventor

Maslivets Andrej NikolaevichDmitriev Maksim ViktorovichBalandina Svetlana YurevnaKamalova Aleksandra RenatovnaSalnikova Tatyana Vladislavovna

(73)

Holder

Federalnoe Gosudarstvennoe Byudzhetnoe Obrazovatelnoe Uchrezhdenie Vysshego Obrazovaniya Gosudarstvennyj Natsionalnyj Issledovatelskij Universitet"

METHOD FOR PREPARATION OF ETHYL 3-(3-HYDROXY-1,4-DIOXO-1,4-DIHYDRONAPHTHALEN-2-YL)-2,5,10-TRIOXO-10b-PHENYL-1,2,3,5,10,10b -HEXAGYDRO-3aH-NAPHTO [2',3':4,5]FURO[3,2-b]PYRROL-3a-CARBOXYLATES Russian patent published in 2018 - IPC C07D491/48 A61K31/407 A61P31/04

Abstract RU 2643372 C1

FIELD: pharmacology.

SUBSTANCE: invention relates to a method for preparation of new compounds - ethyl 3-(3-hydroxy-1,4-dioxo-1,4-dihydronaphthalen-2-yl)-2,5,10-trioxo-10b-phenyl-1,2,3,5,10,10b-hexahydro-3aH-naphtho[2',3':4,5]furo[3,2-b]pyrrole-3a-carboxylates of the general formula I , where R=CH₂Ph(a), C₆H₁₁-c(b), Ph(c), C₆H₄OMe-4 (d), C₆H₄Me-4 (e), C₆H₄Cl-4 (f), Me(g) by reacting 5-phenyl-4-ethoxycarbonyl-1H-pyrrole-2,3-dione with 2-hydroxynaphthalene-1,4-dione in a 1:2 ratio in the presence of acetic acid in an inert aprotic solvent environment.

EFFECT: obtaining of new compounds that can be used as ingredients for synthesis of new heterocyclic systems and in pharmacology as having antimicrobial activity.

3 cl, 1 tbl, 2 ex

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RU 2 643 372 C1

Authors

Maslivets Andrej Nikolaevich

Dmitriev Maksim Viktorovich

Balandina Svetlana Yurevna

Kamalova Aleksandra Renatovna

Salnikova Tatyana Vladislavovna

Dates

2018-02-01—Published

2017-08-07—Filed