FIELD: organic chemistry.
SUBSTANCE: present invention relates to the field of organic chemistry, namely the use of 3-aroyl-2-hydroxy-3a-(2-oxoindolin-3-yl)-1H-benzo[b]pyrrolo[1,2-d][1,4 ]-oxazine-1,4(3aH)-diones, 3-aroyl-2-hydroxy-3a-(2-oxo-5-fluoroindolin-3-yl)-1H-benzo[b]pyrrolo[1,2-d ][1,4]-oxazine-1,4(3aH)-dione of formula (3a-d), where: R1=R2=H (a), R1=Cl, R2=H (b), R1=Br, R2=H (c), R1=H, R2=F (d) as an anti-inflammatory agent.
EFFECT: detection of previously unknown anti-inflammatory activity of 3-aroyl-2-hydroxy-3a-(2-oxoindolin-3-yl)-1H-benzo[b]pyrrolo[1,2-d][1,4]-oxazin-1,4 (3aH)-diones and 3-aroyl-2-hydroxy-3a-(2-oxo-5-fluoroindolin-3-yl)-1H-benzo[b]pyrrolo[1,2-d][1,4]- oxazine-1,4(3aH)-diones.
1 cl, 1 tbl, 5 ex
| Title |
Year |
Author |
Number |
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|
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