METHOD FOR PREDICTING THE EFFICIENCY OF HALOPERIDOL THERAPY FOR THE TREATMENT OF DISORDERS ACCOMPANIED BY THE DEVELOPMENT OF PSYCHOTIC SYMPTOMS Russian patent published in 2018 - IPC G01N33/48 

FIELD: medicine; pharmaceuticals.

SUBSTANCE: invention relates to medicine, namely pharmacogenetics, clinical pharmacology, psychiatry, narcology, and can be used to select the dose of an antipsychotic drug from the group of haloperidol bootosterophen derivatives in patients with any nosology. Method of optimizing the haloperidol dosage regimes for the treatment of disorders accompanied by the development of psychotic symptoms, based on the results of genotyping using polymorphic markers of CYP2D6 and CYP3A4 genes is that the resulting change in the rate of biotransformation of haloperidol (parameter P) is calculated, and if the change is defined as the deviation of the haloperidol biotransformation rate by 50 % or more, it is recommended to replace the drug; if the change is defined as a reduction of the haloteradol biotransformation rate by less than 50 % – a dose reduction is recommended; if the change is defined as an increase in the haloperidol biotransformation rate by less than 50 % – a dose increase is recommended.

EFFECT: method for optimizing the haloperidol dosage regimes for the treatment of disorders accompanied by the development of psychotic symptoms.

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