FIELD: medicine.
SUBSTANCE: invention refers to medicine, particularly to pharmacogenetics, clinical pharmacology, psychiatry and addictology. Disclosed is a method for optimizing dosing regimen promazine for treating psychotic symptomatic disorders by genotyping using polymorphic markers of CYP2D6 genes. Performing the resulting speed change calculation biotransformation promazine (parameter P). If change is defined as speed deviation biotransformation of promazine by 50 % and higher, replacement of the drug is recommended. If change is defined as deceleration of speed biotransformation of promazine less than by 50 %, dose reduction is recommended. If change is defined as speed acceleration biotransformation of promazine more than by 50 %, dose increase is recommended.
EFFECT: invention has high accuracy, information content and objectivity.
1 cl, 1 tbl
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