FIELD: chemistry.
SUBSTANCE: invention relates to the method for producing methyl 3-[3-((cyclohexylcarbonyl){[4'-(dimethylamino)biphenyl-4-yl]methyl}amino)phenyl]acrylate(phexaramine), that is an agonist of the farnesoid X-receptor (FXR). The method is carried out by the liquid-phase method by the reaction of methyl 3-(3-aminophenyl)acrylate with 4'-(dimethylamino)biphenyl-4-carbaldehyde and the subsequent acylation of the obtained methyl 3-[3-({[4'-(dimethylamino)biphenyl-4-yl]methyl}amino) phenyl]acrylate with cyclohexanecarbonitrile.
EFFECT: method allows you to simplify the process, to reduce its cost and to produce the target product with a high purity.
1 tbl, 2 ex
| Title | Year | Author | Number |
|---|---|---|---|
| METHOD FOR SYNTHESIS OF (Z)-3-(2-BUTOXY-3'-(3-HEPTYL-1-METHYLUREIDO) BIPHENYL-4-YL)-2-METHOXYACRYLIC ACID | 2008 |
|
RU2478614C2 |
| (S)-METHYL-3-(3-NITROPHENYL)PENTANOATE | 1998 |
|
RU2263106C2 |
| NEW DERIVATIVES OF 3-PHENYLPROPIONIC ACID | 2006 |
|
RU2369602C2 |
| METHOD OF OBTAINING 4-AMINO-3-QUINOLINECARBONITRYLS | 2004 |
|
RU2345069C2 |
| METHOD FOR PRODUCTION OF 7-SUBSTITUTED-3-QUINOLINE AND 3-QUINOL-4-ON CARBONITRYLES | 2003 |
|
RU2309149C2 |
| PROCESS FOR PREPARATION OF N-[(3-AMINOOXETAN-3-YL)METHYL]-2-(1,1-DIOXO-3,5-DIHYDRO-1,4-BENZOTHIAZEPINE-4-YL)-6-METHYL-QUINAZOLINE-4-AMINE | 2015 |
|
RU2664643C2 |
| METHOD FOR PRODUCING HERBICIDE TRIFLUSULFURON-METHYL | 2021 |
|
RU2758839C1 |
| SUBSTITUTED METHYL(2-{4-[3-(3-METHANESULFONYLAMINO-2-FLUORO-5-CHLORO-PHENYL)-1H-PYRAZOL-4-YL]PYRIMIDIN-2-YLAMINO}ETHYL) CARBAMATES, PROCESS FOR THEIR PREPARATION AND APPLICATION | 2016 |
|
RU2615986C1 |
| 4-PYRIMIDINE- OR PYRIDINYL DERIVATIVES OF INDOLE-3-YL-ALKYLPIPERAZINES, PHARMACEUTICAL COMPOSITION | 1992 |
|
RU2114111C1 |
| 3-ARYLBENZOFURANONES, STABILIZED COMPOSITION, AND METHOD OF STABILIZATION | 1994 |
|
RU2134689C1 |
