FIELD: organic chemistry, biochemistry.
SUBSTANCE: invention relates to a new intermediate compound, namely, (S)-methyl-3-(3-nitrophenyl)pentanoate that is used in preparing [R-(R*,R*)]-N-[3-[1-[5,6-dihydro-4-hydroxy-2-oxo-6-(2-phenylethyl-6-propyl-2H-pyran-3-yl]propyl]phenyl]-5-(trifluoromethyl)-2-pyridinsulfonamide representing a protease inhibitor. This inhibitor can be used in treatment of HIV-infected patients. Invention provides preparing new intermediate compound for the new protease inhibitor.
EFFECT: valuable medicinal and antiviral properties of compound.
1 cl, 3 sch, 9 ex
Title | Year | Author | Number |
---|---|---|---|
4-HYDROXYPYRAN-2-ONES, CYCLOOCTYL- OR BENZOPYRAN-2-ONES, 4-HYDROXY-2H-PYRAN-2-ONES AND HYDROXYCYCLOOCTANEPYRAN-2- ONES | 1995 |
|
RU2139284C1 |
4-HYDROXYBENZOPYRAN-2-ONE OR 4-HYDROXYCYCLOALKYL[B]BENZOPYRAN- -2-ONE AND, METHOD OF SYNTHESIS OF N-[3-[CYCLOPROPYL- -(5,6,7,8,9,10-HEXAHYDRO-4-HYDROXY-2-OXO-2H-CYCLOOCTA[B]- -PYRAN-3-YL)METHYL]PHENYL]-BENZENESULFONE | 1994 |
|
RU2125999C1 |
SUBSTITUTED PYRIMIDINETHIOALKYL OR ALKYLESTER COMPOUNDS AND METHOD OF INHIBITION OF VIRAL REVERSE TRANSCRIPTASE ACTIVITY | 1996 |
|
RU2167155C2 |
METHOD OF SYNTHESIS OF NITROGEN-CONTAINING HETEROCYCLIC COMPOUNDS OR THEIR PHARMACEUTICALLY ACCEPTABLE SALTS | 1990 |
|
RU2026296C1 |
TRICYCLIC COMPOUNDS OF BENZOPYRAN AS ANTIARRHYTHMIC AGENTS | 2005 |
|
RU2380370C2 |
NEW DERIVATIVES OF HYDROXAMIC ACID USEFUL FOR TREATMENT OF PATIENTS WITH DISEASES ASSOCIATED WITH DEGENERATION OF CONNECTIVE TISSUE | 1997 |
|
RU2168497C2 |
DERIVATIVES OF BENZAZEPINE AND BENZOTHIAZEPINE | 1989 |
|
RU2090562C1 |
HETEROCYCLIC MUSCARINIC AGONISTS AND COMPOSITIONS, THEIR USING AND METHODS FOR TREATMENT | 2002 |
|
RU2292346C2 |
TETRACYCLIC HETEROCOMPOUNDS AS ESTROGEN RECEPTOR MODULATING AGENTS | 2002 |
|
RU2305099C2 |
NEW TETRACYCLIC COMPOUNDS CONTAINING HETEROATOM, USED AS SELECTIVE MODULATORS OF OESTROGEN RECEPTORS | 2003 |
|
RU2331645C2 |
Authors
Dates
2005-10-27—Published
1998-09-03—Filed