NEW CONNECTING C5a NUCLEIC ACIDS Russian patent published in 2018 - IPC C12N15/115 A61K31/7088 A61P29/00 

FIELD: biotechnology.

SUBSTANCE: L-nucleic acid molecule capable of binding to human C5a, wherein the L-nucleic acid molecule contains a central nucleotide region, wherein the central nucleotide region contains the nucleotide sequence 5' AUGn₁GGUGKUn₂n₃RGGGHUGUKGGGn₄Gn₅CGACGCA 3' [SEQ ID NO: 61], wherein n₁ is U or dU, n₂ is G or dG, n₃ is A or dA, n₄ is U or dU, n₅ is U or dU, and G, A, U, C, H, K, and R are ribonucleotides, and dU, dG, and dA are 2'-deoxyribonucleotides. The use of this molecule for the treatment or prevention of a disease associated with complement activation and C5a mediated pathogenic mechanisms is also described. The use of this molecule in the diagnosis of this disease is also described. A method for detecting the mentioned molecule in a sample is also described.

EFFECT: higher efficacy of compound application.

26 cl, 23 dwg, 1 tbl, 10 ex