ARYL UREA DERIVATIVES AS N-FORMILEPEPTIDE-1 RECEPTOR (FPRL-1) MODULATORS Russian patent published in 2017 - IPC C07C275/30 C07C275/42 C07C323/44 C07D209/20 C07D213/55 C07D213/75 C07D239/84 A61P27/02 

Abstract RU 2627271 C2

FIELD: pharmacology.

SUBSTANCE: invention relates to a compound represented by formula , or pharmaceutically acceptable salts thereof, wherein R6 is -CH2-(C6-10)aryl or -CH2-heterocycle, wherein the heterocycle is pyridine or indole; R7 is H, F or methyl; R8 is Br or F; R9 is H, F or methyl; R10 is OH or NH2; and including specific structures or pharmaceutically acceptable salts thereof. The invention also relates to a compound represented by formula , or pharmaceutically acceptable salts thereof, wherein R11 is C1-C6 alkyl; R12 is H; R13 is Br; R14 is H; R15 is OH or NH2; R16 is C1-C6 alkyl. and

EFFECT: aryl urea derivatives as N-formylpeptide receptor-1 modulators.

14 cl, 6 tbl, 6 ex

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RU 2 627 271 C2

Authors

Bird Richard L.

Duong Ten T.

Donello Dzhon E.

Visvanat Veena

Garst Majkl E.

Dates

2017-08-04Published

2012-11-06Filed