FIELD: pharmacology.
SUBSTANCE: invention relates to a compound represented by formula , or pharmaceutically acceptable salts thereof, wherein R6 is -CH2-(C6-10)aryl or -CH2-heterocycle, wherein the heterocycle is pyridine or indole; R7 is H, F or methyl; R8 is Br or F; R9 is H, F or methyl; R10 is OH or NH2; and including specific structures or pharmaceutically acceptable salts thereof. The invention also relates to a compound represented by formula , or pharmaceutically acceptable salts thereof, wherein R11 is C1-C6 alkyl; R12 is H; R13 is Br; R14 is H; R15 is OH or NH2; R16 is C1-C6 alkyl. and
EFFECT: aryl urea derivatives as N-formylpeptide receptor-1 modulators.
14 cl, 6 tbl, 6 ex
Authors
Dates
2017-08-04—Published
2012-11-06—Filed