SOLID DISPERSIONS OF INSOLUBLE DRUGS AND METHODS OF THEIR PREPARATION Russian patent published in 2018 - IPC A61K31/42 A61K47/30 A61K47/00 A61K9/14 A61K9/20 A61J3/02 A61P25/00 A61P25/28 

FIELD: pharmaceuticals.

SUBSTANCE: present invention refers to solid pharmaceutical dispersion, which contains 3-(4-benzyloxyphenyl)-isoxazol-5-ylmethyl carbamic acid as the active ingredient, the water soluble polymer that has the glass transition temperature below the melting point of the active ingredient as the carrying agent and the softening agent. Solid dispersion is prepared by means of melt extrusion. Water-soluble polymer is selected from polyvinylpyrrolidone, hypromellose acetate succinate and combinations thereof. Softener is selected from the group, which consists of D-alpha-tocopheryl polyethylene glycol 1000 succinate, polyethylene glycol 400 and combinations thereof. Method for preparing the solid dispersion and the pharmaceutical composition that includes the solid dispersion are also disclosed and are intended for the treatment of degenerative brain disease.

EFFECT: solid dispersion of the present invention increases the solubility and dissolution rate of the active ingredient, which is the insoluble drug, for effective improvement of bioavailability during oral administration.

9 cl, 3 dwg, 13 tbl, 7 ex