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2 646 604

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IPC

C07K5/62(2006-01-01)

A61K38/05(2006-01-01)

A61P25/00(2006-01-01)

(21) (22)

Application

2016100425, 2016-01-12

(24)

Start date

2016-01-12

(22)

Actual filing date

2016-01-12

(45)

Published

2018-03-06

(72)

Inventor

Seredenin Sergej BorisovichGudasheva Tatyana AleksandrovnaKolyasnikova Kseniya NikolaevnaKuznetsova Elena AleksandrovnaVoronina Tatyana AleksandrovnaYarkova Milada AlnordovnaAntipova Tatyana AlekseevnaLitvinova Svetlana AleksandrovnaZolotov Nikolaj Nikolaevich

(73)

Holder

Federalnoe Gosudarstvennoe Byudzhetnoe Nauchnoe Uchrezhdenie Institut Farmakologii Imeni V.V. Zakusova"

NOVEL GLYPROLINS WITH NOOTROPIC, ANTI-HYPOXIC, NEUROPROTECTIVE AND ANSSIYLITIS ACTIVITY Russian patent published in 2018 - IPC C07K5/62 A61K38/05 A61P25/00

Abstract RU 2646604 C2

FIELD: pharmaceutics.

SUBSTANCE: invention relates to novel N-phenylacetyl-substituted glyiprolines of the general formula: C₆H₅-CH₂-C(O)-Gly-X-Pro-R, where X represents an L- or D-configuration, R = OCH₃, or OC₂H₅, or NH₂, or NHCH₃. Novel compounds possess neuropsychotropic activity, including nootropic, neuroprotective, antihypoxic and anxiolytic activity and can be used as pharmaceutical agents; funds for the treatment of violations of cognitive functions, anxiety and neurodegenerative disorders.

EFFECT: can be used as pharmaceutical agents, agents for the treatment of cognitive impairment, anxiety disorders and neurodegenerative disorders.

8 cl, 1 dwg, 7 tbl, 7 ex

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RU 2 646 604 C2

Authors

Seredenin Sergej Borisovich

Gudasheva Tatyana Aleksandrovna

Kolyasnikova Kseniya Nikolaevna

Kuznetsova Elena Aleksandrovna

Voronina Tatyana Aleksandrovna

Yarkova Milada Alnordovna

Antipova Tatyana Alekseevna

Litvinova Svetlana Aleksandrovna

Zolotov Nikolaj Nikolaevich

Dates

2018-03-06—Published

2016-01-12—Filed