FIELD: pharmaceuticals.
SUBSTANCE: invention relates to novel coumarin derivative of the following formula (I) or pharmaceutically acceptable salt or hydrate thereof, where R1 and R2 are the same or different and are (a) phenyl optionally substituted by alkoxy, alkyl, cyano, nitro, hydroxy, trifluoromethyl, amino, carboxy, alkoxycarbonyl, phenyl or one or two halogen atoms, (b) pyridyl, (c) alkyl or (d) thienyl, as well as a pharmaceutical agent containing such a compound as active ingredient. 
.
EFFECT: coumarin derivative of formula I or pharmaceutically acceptable salt and hydrate thereof exhibits excellent inhibitory effect on cartilage destruction and inhibitory effect on the proliferation of synovial cells in a pharmacological test, in which release of sulfated glycosaminoglycans (sGAG) and the proliferation of synovial cells are used as indicators, whereby said compound is very useful as active ingredient of a pharmaceutical composition, such as a preventive or therapeutic agent for the treatment of arthropathy, such as osteoarthritis or chronic rheumatoid arthritis.
23 cl, 11 tbl, 5 ex
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