SUBSTITUTED AMINOALKYL- AND AMIDOALKYLBENZOPYRAN DERIVATIVES Russian patent published in 2010 - IPC C07D311/06 C07D311/58 C07D311/74 A61K31/353 A61K31/37 A61P25/00 

FIELD: chemistry.

SUBSTANCE: invention refers to novel aminoalkyl-and amodialkylbenzopyran derivatives of the general formula (I): (a), where (a) group is a substitute in 6 or 7 position, where R is mono- or bicyclic (C₆-C₁₀)-aryl radical optionally substituted with one or two substitutes selected out of linear or ramified (C₁-C₅)-alkyls, linear or ramified (C₁-C₅)-alkoxy, hydroxy, halogen and trifluoromethyl; m is zero or integer 1-3; n, p, R₁ and R₂ are as indicated in the description, and both R₃ and R₄ are hydrogen or both are oxygen: and to pharmaceutically acceptable salts thereof.

EFFECT: selective reversible MAO-B inhibitors in vitro and in vivo, applicable as medicines for prevention and treatment of degenerative central nervous system disorders.

13 cl, 24 ex