DERIVATIVES OF PROPIONIC ACID AND PHARMACEUTICAL COMPOSITION BASED ON THEREOF Russian patent published in 2001 - IPC

FIELD: organic chemistry, pharmacy. SUBSTANCE: invention relates to novel derivatives of propionic acid of the formula (I) where R means the group of the formula (II) or (III) ; R' means phenyl or benzothienyl; R⁵ means lower alkyl; R⁴ means hydrogen atom; R⁶ means hydrogen atom or in common with R⁹ it forms a double bond; R⁷ means carboxy-group, acyl, alkoxycarbonyl, optionally substituted lower alkyl, optionally substituted carbamoyl, arylhydroxycarbonyl, aralkylhydroxycarbonyl or the group of the formula -Y-R⁸ where Y means -NH- or oxygen atom; R⁸ means acyl-group or alcoxycarbonyl-group; R⁹ means hydrogen atom, optionally substituted lower alkyl or lower alkoxycarbonyl- -group; R¹⁰ means hydroxy-group optionally substituted with lower alkyl, amino-group, lower alkoxy-group, lower alkyl, phenoxy-group or aralkylhydroxy-group under condition that if R⁷ means alkoxycarbonyl-group and R⁹ means hydrogen atom then R¹⁰ is not lower alkoxy-group; or their pharmaceutically acceptable salts. Invention relates to also a pharmaceutical composition eliciting hypoglycaemic activity and containing the compound of the formula (I) and pharmaceutically acceptable carrier or other additions. Derivatives of propionic acid can be used as therapeutic agents for treatment of diabetic patients. EFFECT: development of new compounds used for treatment of diabetic patients. 7 cl, 2 tbl, 63 ex