VACCINE AGAINST TUBERCULOSIS Russian patent published in 2018 - IPC A61K39/04 A61K39/39 A61P31/06 

FIELD: medicine.

SUBSTANCE: invention refers to medicine, namely to immunology, and may be used to obtain a vaccine against tuberculosis. Vaccine contains an active principle based on mycobacteria tuberculosis and excipients, as an active principle, it contains the protein Tb10.4 M. tuberculosis and Ag85B M. tuberculosis in a ratio from 1:2 to 2:1 with the following ratio of ingredients, mass%: protein Tb10.4 M. tuberculosis 0.001–0.003; Ag85B M. tuberculosis 0.001–0.003; fusion protein based on FliC Salmonella typhimurium at a concentration of 0.001-0.0030; auxiliary substances 4.5–5.5; water – the rest.

EFFECT: use of a hybrid protein on the basis of FliC Salmonella typhimurium as a part of the vaccine makes it possible to neutralize the side-effects of the live vaccine use, resulting vaccine exhibits protective activity both in intramuscular and intranasal administration.

4 cl, 1 ex, 1 tbl