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2 647 833

(13)

(51)

IPC

A61K45/00(2006-01-01)

A61P7/00(2006-01-01)

A61K31/416(2006-01-01)

A61K31/4995(2006-01-01)

A61K39/00(2006-01-01)

(21) (22)

Application

2017118297, 2017-05-25

(24)

Start date

2017-05-25

(22)

Actual filing date

2017-05-25

(45)

Published

2018-03-19

(72)

Inventor

Zyuzkov Gleb NikolaevichUdut Elena VladimirovnaMiroshnichenko Larisa ArkadevnaPolyakova Tatyana YurevnaSimanina Elena VladislovovnaStavrova Larisa AleksandrovnaZhdanov Vadim VadimovichChajkovskij Aleksandr Vasilevich

(73)

Holder

Federalnoe Gosudarstvennoe Byudzhetnoe Nauchnoe Uchrezhdenie Natsionalnyj Issledovatelskij Meditsinskij Tsentr Rossijskoj Akademii Nauk" Nimts)

HEMOSTIMULATING AGENT Russian patent published in 2018 - IPC A61K45/00 A61P7/00 A61K31/416 A61K31/4995 A61K39/00

Abstract RU 2647833 C1

FIELD: medicine.

SUBSTANCE: invention relates to medicine, specifically to pharmacology and hematology. Use of the JNK inhibitor (c-Jun N-terminal kinase) as a hemostimulating agent under conditions of cytostatic myelosuppression has been proposed. JNK IQ-IS and SP600125 inhibitors up to 238.2 % and up to 250.2 %, respectively, increased the content of mature neutrophil granulocytes in the bone marrow of mice after cytostatic myelosuppression caused by 5-FU, also increased the erythroid cells content.

EFFECT: invention provides an expansion of the arsenal of highly effective hemostimulating agents.

1 cl, 3 tbl, 1 ex

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RU 2 647 833 C1

Authors

Zyuzkov Gleb Nikolaevich

Udut Elena Vladimirovna

Miroshnichenko Larisa Arkadevna

Polyakova Tatyana Yurevna

Simanina Elena Vladislovovna

Stavrova Larisa Aleksandrovna

Zhdanov Vadim Vadimovich

Chajkovskij Aleksandr Vasilevich

Dates

2018-03-19—Published

2017-05-25—Filed