STABILIZER FOR HYALURONIDASE AND LIQUID COMPOSITION, WHICH CONTAINS HYALURONIDASE Russian patent published in 2018 - IPC A61K38/47 A61K47/00 A61K9/08 

FIELD: chemistry.

SUBSTANCE: invention refers to the stable aqueous composition, which comprises hyaluronidase, the stabilizer for hyaluronidase and water as a solvent. Hyaluronidase is extracted from the testis of one or more mammals, excluding humans, and has the purity of 95 % or more and the specific activity of 70,000 IU/mg or more. Hyaluronidase stabilizer consists of the buffering agent for the provision of pH from 4.0 up to 6.0, the non-ionic surfactant from 0.001 up to 0.01 vol/vol% and from 0.1 up to 1 mM of ethylendiaminetetraacetic acid as the chelating agent or MgCl₂. Hyaluronidase is purified from the hyaluronidase-containing material by means of application of affinity chromatography, ion exchange chromatography or gel filtration.

EFFECT: aqueous hyaluronidase composition of the invention is characterized by improved stability and can replace the lyophilized hyaluronidase compositions.

18 cl, 8 dwg, 21 tbl, 8 ex