FIELD: medicine; pharmaceuticals.
SUBSTANCE: invention refers to the new method for the preparation of indolo[1',7':1,2,3]pyrrolo[3',4':6,7]azepino[4,5-b]indole-1,3(2H,10H)-dione, which is the starting material for the preparation of the potential antitumor preparation of 6-[(4-methyl-1-1-piperazinyl)methyl]-indolo[1',7':1,2,3]pyrrolo[3',4':6,7]azepino[4,5-6]indole-1,3(2H,10H)-dione). Method includes the steps of introducing the protecting group along the indole nitrogen atom, the subsequent dehydrogenation step under the action of 2,3-dichloro-5,6-dicyanobenzoquinone, and the step of protective group removal.
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EFFECT: claimed method allows to increase the yield of the final product more than twice as compared with the known method.
1 cl, 6 ex
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|---|---|---|---|
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