FIELD: organic chemistry.
SUBSTANCE: intended for the production of new individual compounds of the 4-aroyl-1-(2-hydroxyaryl)-5-(1H-indol-3-yl)-1,3-dihydro-2H-pyrrole-2, 3-diones class. A method is presented for the preparation of 4-aroyl-1-(2-hydroxyaryl)-5-(1 H -indol-3-yl)-1,3-dihydro-2 H -pyrrole-2,3-diones of formula IIa-d by oxidation with oxygen air 3-aroyl-2-hydroxy-3a-(1H- indol-3-yl)-1H-pyrrolo[2,1-c][1,4]benzoxazine-1,4(3aH)-diones Ia-d, where I and II: Ar = Ph, R = H (a); Ar = C6H4F-4, R = H (b); Ar = C6H4Cl-4, R = H (c); Ar = C6H4Br-4, R = H (g); Ar = C6H4CH3-4, R = H (d), carried out by keeping the reagents at room temperature in acetone according to the indicated scheme.
EFFECT: providing the production of 4-aroyl-1-(2-hydroxyaryl)-5-(1H-indol-3-yl)-1,3-dihydro-2H-pyrrole-2,3-diones with antimicrobial activity.
1 cl, 1 tbl, 4 ex
| Title |
Year |
Author |
Number |
| METHOD FOR PRODUCING 3-AROYL-4-HYDROXY-1-(2-HYDROXYARYL)-1',3'-DIMETHYLSPIRO[PYRROLE-2,5'-PYRROLO[2,3-d]PYRIMIDINE]-2',4', 5,6'(1H,1'H,3'H,7'H)-TETRAONES WITH ANTIMICROBIAL ACTIVITY |
2023 |
- Maslivets Andrei Nikolaevich
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- Kobelev Aleksandr Ivanovich
|
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2013 |
- Stepanova Ekaterina Evgen'Evna
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- Makhmudov Ramiz Ragibovich
|
RU2556998C2 |
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|
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2021 |
- Maslivets Andrej Nikolaevich
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|
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2015 |
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|
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2022 |
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|
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2023 |
- Maslivets Andrei Nikolaevich
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2018 |
- Maslivets Andrej Nikolaevich
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|
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2022 |
- Mashevskaia Irina Vladimirovna
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|
RU2783287C1 |
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2016 |
- Stepanova Ekaterina Evgenevna
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|
RU2631432C1 |
