FIELD: biotechnology; pharmaceutics.
SUBSTANCE: present invention relates to biotechnology and pharmaceutics, namely to pharmaceutical composition applicable for inhibiting anti-VEGF agents resistant tumor growth. This composition comprises an anti-IL-6R antibody and a VEGF antagonist. Present invention discloses methods for inhibiting growth of anti-VEGF agents resistant tumors in a subject using said composition.
EFFECT: present invention allows to increase efficacy of treating tumors resistant to anti-VEGF agents, which have a higher IL-6/STAT3 signaling compared to a tumor sensitive to the VEGF antagonist itself.
24 cl, 2 dwg, 7 tbl, 2 ex
