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(19)

RU

(11)

2 587 619

(13)

C2

(51)

IPC

C07K14/475(2006-01-01)

A61K38/18(2006-01-01)

A61P35/00(2006-01-01)

(21) (22)

Application

2012139825/10, 2011-02-17

(24)

Start date

2011-02-17

(22)

Actual filing date

2011-02-17

(45)

Published

2016-06-20

(72)

Inventor

Dzhekson ErikaSvit-Kordero Erik Alekhandro

(73)

Holder

Dzhenentek, Ink.Dze Bord Of Trastiz Of Dze Lelend Stenford Dzhunior Yuniversiti

NEUREGULIN ANTAGONISTS AND USE THEREOF IN TREATING MALIGNANT GROWTH Russian patent published in 2016 - IPC C07K14/475 A61K38/18 A61P35/00 

Abstract RU 2587619 C2

FIELD: biotechnology.

SUBSTANCE: invention relates to method of increasing period of time to recurrence, and can be used in medicine. Neuregulin antagonists are obtained, which are anti-NRG1 antibody siRNK or shRNK targeted NRG1, or immune-adhesine to NRG1 for administering the previously recieved anticancer therapy, in combination with therapeutic agent specified in paclitaxel, cisplatin or their combination for delay time to recurrence or prevent development of cancer cell resistance to therapeutic agent.

EFFECT: invention allows to increase period of time to recurrence, which increases survival rate of patients.

10 cl, 8 dwg, 1 tbl, 8 ex

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RU 2 587 619 C2

Authors

Dzhekson Erika

Svit-Kordero Erik Alekhandro

Dates

2016-06-20—Published

2011-02-17—Filed

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