COMBINATION THERAPY USING TYPE II ANTI-CD20 ANTIBODY AND SELECTIVE BCL-2 INHIBITOR Russian patent published in 2018 - IPC A61K39/395 A61K31/496 A61P35/02 

Abstract RU 2648476 C2

FIELD: medicine.

SUBSTANCE: group of inventions relates to medicine, namely to oncology, and can be used in treatment of cancer. Methods of the invention include administration of a combination of antibody GA101 and 2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)-4-(4-((2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-enyl)methyl)piperazin-1-yl)-N-(3-nitro-4-((tetrahydro-2H-pyran-4-yl)methylamino)phenylsulfonyl)benzamide (GDC-0199).

EFFECT: use of inventions allows to increase effectiveness of treatment.

22 cl, 5 dwg, 4 ex, 2 tbl

Similar patents RU2648476C2

Title Year Author Number
COMBINED THERAPY BASED ON CD20 ANTIBODY COMBINED WITH BCL-2 INHIBITOR AND MDM2 INHIBITOR 2016
  • Klyajn Kristian
  • Kherting Frank
  • Dangl Markus
RU2727196C2
COMBINED THERAPY WITH AFUCOSYLATED CD20 ANTIBODY AND mTOR INHIBITOR 2011
  • Gerting Frank
  • Klyajn Kristian
RU2585489C2
THERAPY OF METASTATIC UROTHELIAL CANCER USING ANTIBODY-DRUG CONJUGATE SATSITUZUMAB GOVITECAN (IMMU-132) 2017
  • Govindan Serengulam V.
  • Goldenberg David M.
RU2757395C2
COMBINED THERAPY BY AFUCOSYLATED ANTIBODY FOR CD20 WITH ANTIBODY FOR VEGF 2011
  • Gerting Frank
  • Klyajn Kristian
RU2615459C2
EFFICACY OF CONJUGATES OF ANTI-TROP-2 ANTIBODY WITH DRUG SN-38 FOR THERAPY OF RECURRENT/REFRACTORY TO INHIBITORS OF TUMOR CONTROL POINT 2017
  • Govindan Serengulam V.
  • Goldenberg David M.
RU2725292C2
TREATMENT OF TRIPLE-NEGATIVE BREAST CANCER CHARACTERIZED BY Trop-2 EXPRESSION USING SATSITUZUMAB GOVITECAN AND Rad51 INHIBITOR 2018
  • Cardillo Thomas M.
  • Goldenberg David M.
RU2758234C2
COMBINED METHODS FOR TREATING WITH PD-L1 ANTAGONISTS 2016
  • Endryus Glen Ajan
  • Chen Shikhao
  • Di Petro Alessandra
  • Fontana Dejvid
  • Goldberg Zelanna
  • Lin Chia-Yan
  • Long Khua
  • Martinoni Marsella
  • Nujten Dmitrij Serzh Antuan
  • Toll Aron Dejvid
  • Vulfson Adrian
RU2766890C2
TREATMENT APPROACH DESIGNED TO TREAT WITH A COMBINATION OF ANTI-CD19 ANTIBODY AND VENETOCLAX 2018
  • Kelemen Peter
  • Schwarz Michael
  • Winderlich Mark
  • Heeger Steffen
  • Weinelt Dominika
RU2802812C2
COMBINED THERAPY BASED ON CD20 ANTIBODY AND BTK INHIBITOR 2014
  • Klajn Kristian
  • Toshio Joshizava
  • Tomoko Yasukhiro
RU2727650C2
TREATING A MALIGNANT TUMOR USING A CHIMERIC ANTIGEN CD19 RECEPTOR 2015
  • Brogdon, Jennifer
  • Byrd, John
  • Dubovsky, Jason
  • Fraietta, Joseph
  • Gill, Saar
  • Glass, David
  • Johnson, Amy
  • June, Carl, H.
  • Kenderian, Saad
  • Mannick, Joan
  • Maus, Marcela
  • Murphy, Leon
  • Muthusamy, Natarajan
  • Porter, David L.
  • Ruella, Marco
  • Sellers, William Raj
  • Wasik, Mariusz
RU2718542C2

RU 2 648 476 C2

Authors

Sampatkh Dipak

Klyajn Kristian

Fejrbrazer Uejn Dzhon

Dates

2018-03-26Published

2013-09-06Filed