METHOD FOR SYNTHESIS OF HYDRAZINE, WHICH CAN BE USED IN TREATMENT OF PAPILLOMA VIRUS Russian patent published in 2018 - IPC C07D295/135 C07D295/155 

FIELD: chemistry.

SUBSTANCE: invention relates to a process for the preparation of a compound of general formula (I) and pharmaceutically acceptable salts thereof from an amine of formula (II) using urea of formula (III) as the synthesis intermediate. According to the disclosed process, urea of formula (III) is prepared from an amine of formula (II) according to the following steps: (1) reacting an amine of formula (II) and Cl₃CC(O)-N=C=O to obtain a compound having formula (IV); (2) treating, in an alkaline medium, the compound of formula (IV) obtained in the previous step to obtain a urea of formula (III). Compound of formula (I) is then obtained from the urea of formula (III) via Shestakov regrouping. Invention also relates to a process for the preparation of a compound of formula (V) and a compound of formula (III). In the formulae (I) - (V) G₁ is a link, A is an aryl group, such as phenyl substituted in the para position with a (C_5-10)aryl-(C_1-6)alkyl group, and B is an aryl group such as phenyl substituted in the ortho position with a heterocycle, such as a piperidin-1-yl group, and substituted in ortho'-position by an alkyl group, such as methyl. , , , , .

EFFECT: method enables to prepare hydrazines of formula (I), which can be used in the synthesis of compounds of formula (V), used in the treatment of infection caused by the papilloma virus.

8 cl, 4 ex