3-ALKYLIDENHYDRAZINO-HETEROARYL COMPOUNDS AS ACTIVATORS OF THROMBOPROTEIN RECEPTOR Russian patent published in 2009 - IPC C07D231/18 C07D333/32 A61K31/415 A61K31/381 A61P7/00 A61P35/00 

FIELD: chemistry.

SUBSTANCE: in compounds with formula (1) A is a nitrogen atom or CR⁴, where R⁴ is a hydrogen atom, halogen atom; B is a sulphur atom or NR⁹, where R⁹ is a hydrogen atom, hydroxyl group, formyl group, C_1-6 alkyl group, under the condition that, when A is a nitrogen atom, B is not NH; R¹ is a phenyl group, which can be substituted with one or several substitutes, chosen from a group comprising: a halogen atom, C_1-10 alkyl group, where C_1-10 alkyl group, can optionally be substituted with one or several substitutes, chosen from a group containing a halogen atom; L¹ is a bond; X is OR¹³, where R¹³ is a hydrogen atom; R² is a hydrogen atom, C_1-10 alkyl group, phenyl group; L² is a bond, CR³⁴R³⁵ where each of R³⁴ and R³⁵ independently represent a hydrogen atom or C_1-4 alkyl group; L³ is a NR¹⁹ bond, where R¹⁹ is a hydrogen atom; L⁴ is a bond or NR²², where R²² is a hydrogen atom; Y is an oxygen atom, sulphur atom; and R³ is an aryl group, chosen from phenyl or thienyl, where the aryl group is substituted with a substitute, chosen from a carboxyl group, sulphamide group, C_1-4 alkoxycarbonyl group, tetrazole group and possibly also substituted with a substitute, chosen from halogen atoms, nitro, hydroxyl group, C_1-10 alkylcarbonylamino group.

EFFECT: higher thrombocyte level.

33 cl, 13 dwg, 7 tbl, 181 ex