FIELD: biochemistry.
SUBSTANCE: invention relates to the field of biochemistry, in particular to an isolated antibody or its antigen-binding fragment which binds immunospecifically to a human KIT, a method for its preparation, as well as to the fusion protein and the conjugate comprising the above antibody or antigen-binding fragment thereof. Also disclosed is a polynucleotide encoding the VH and/or VL of the above antibody or its fragment, as well as a vector and a cell containing the above polynucleotide. Also the invention relates to a method for treating a KIT-related disorder, to a method for diagnosing a KIT-related disorder, as well as to a method for induction of apoptosis in a cell expressing KIT using the above antibody or its fragment.
EFFECT: invention makes it possible to effectively treat a KIT-related disorder characterized by an increase in KIT activity or KIT over-expression.
49 cl, 23 tbl, 7 dwg, 9 ex
| Title | Year | Author | Number |
|---|---|---|---|
| ANTIBODIES TO MUC16 AND THEIR APPLICATION | 2016 |
|
RU2758113C2 |
| ANTIBODIES AGAINST HEPATITIS B VIRUS AND THEIR USE | 2020 |
|
RU2803082C2 |
| METHODS OF TREATING S. AUREUS-ASSOCIATED DISEASES | 2013 |
|
RU2661406C2 |
| THERAPEUTIC DLL4-BINDING PROTEINS | 2011 |
|
RU2605928C2 |
| MONOCLONAL ANTIBODIES BINDING WITH hGM-CSF AND COMPOSITIONS FOR MEDICINAL PURPOSES, CONTAINING THEREOF | 2008 |
|
RU2517596C2 |
| NECTIN-4 BINDING PROTEINS AND METHODS OF THEIR APPLICATION | 2018 |
|
RU2805252C2 |
| ANTI c-Met RECEPTOR PROTEIN ANTIBODIES | 2011 |
|
RU2608644C2 |
| ANTIBODIES AGAINST PD-1 AND THEIR USE | 2018 |
|
RU2788616C2 |
| ANTIBODIES AND CHIMERIC ANTIGENIC RECEPTORS SPECIFIC TO CD19 | 2015 |
|
RU2741105C2 |
| IL-6 BINDING MOLECULES | 2013 |
|
RU2676078C2 |
