FIELD: biotechnology.
SUBSTANCE: invention relates to the field of biotechnology, specifically to conjugates containing interleukin 2 (IL2), mutant of tumor necrosis factor alpha (hereinafter – TNF-alpha) and an antibody molecule that binds fibronectin; it can be used in medicine for the treatment of malignant tumor.
EFFECT: invention provides an improvement in the tolerability of double immune-cytokine without changing the efficiency due to the use of TNF-alpha mutant with reduced activity.
15 cl, 5 dwg, 1 tbl, 4 ex
| Title | Year | Author | Number |
|---|---|---|---|
| METHOD FOR PRODUCTION OF ARENAVIRUS, AS WELL AS ARENAVIRUS MUTANTS WITH ANTITUMOR PROPERTIES | 2019 |
|
RU2812046C2 |
| ANTIBODY FOR SPECIFIC BINDING TO N-TERMINAL DOMAIN OF LYSYL-TRNA SYNTHETASE EXPOSED ON EXTRACELLULAR MEMBRANE | 2019 |
|
RU2781304C1 |
| F RSV PROTEIN MUTANTS | 2016 |
|
RU2788403C2 |
| PROTEIN F RSV MUTANTS | 2016 |
|
RU2723039C2 |
| PHARMACEUTICAL COMPOSITION FOR TREATMENT AND/OR PREVENTION OF MALIGNANT TUMOR | 2017 |
|
RU2766586C2 |
| ANTIBODIES TO IL-6 AND THEIR FUSIONS AND CONJUGATES | 2019 |
|
RU2810777C2 |
| TETANUS TOXIN ANTIBODY AND USE THEREOF | 2020 |
|
RU2815280C1 |
| MUTANT NITRILE HYDRATASE, NUCLEIC ACID WHICH ENCODES SAID MUTANT NITRILE HYDRATASE, EXPRESSION VECTOR AND TRANSFORMANT CONTAINING SAID NUCLEIC ACID, METHOD OF PRODUCING SAID MUTANT NITRILE HYDRATASE AND METHOD OF PRODUCING AMIDE COMPOUND | 2017 |
|
RU2736086C1 |
| FUNCTION PROTEIN AND ITS USE | 2019 |
|
RU2800923C2 |
| PREDICTION OF RISK OF DEVELOPMENT OF UNDESIRED REACTION RELATED TO ADMINISTRATION OF ANTIBODY TO ALK2 AND CAPABILITY OF RESPONDING TO TREATMENT WITH ANTIBODY TO ALK2 | 2019 |
|
RU2783762C2 |
