FIELD: biotechnology.
SUBSTANCE: invention relates to the field of biotechnology, specifically to conjugates containing interleukin 2 (IL2), mutant of tumor necrosis factor alpha (hereinafter – TNF-alpha) and an antibody molecule that binds fibronectin; it can be used in medicine for the treatment of malignant tumor.
EFFECT: invention provides an improvement in the tolerability of double immune-cytokine without changing the efficiency due to the use of TNF-alpha mutant with reduced activity.
15 cl, 5 dwg, 1 tbl, 4 ex
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